Making at-home peritoneal dialysis smarter, simpler, and safer
Making at-home peritoneal dialysis smarter, simpler, and safer
DialySafe is developing a patient-centered solution to make peritoneal dialysis smarter, simpler, and safer especially for pediatric patients and their families. Our technology enables real-time infection detection via a novel, low-cost capacitance-based sensor.
DialySafe’s patent-pending technology enables real-time, objective monitoring of dialysis effluent using a capacitance-based sensing approach. Our easy-to-use, clip-on hardware integrates seamlessly into existing PD workflows: simply attach it to the fill and drain lines.
Inside the device, built-in copper electrodes form a capacitor with the dialysis fluid acting as the dielectric. As infection progresses, the effluent becomes increasingly filled with biological debris including bacteria and white blood cells which alters the fluid’s dielectric properties on a molecular level. These changes produce a detectable electrical signal.
To ensure accuracy without added burden, the system uses a differential measurement approach: it compares the capacitance of the clean fill fluid to that of the used drain effluent, automatically rejecting common-mode noise and eliminating the need for manual calibration.
Key features extracted from the signal are then analyzed by our trained machine learning algorithm, which classifies infection risk as low, medium, or high all in real-time and fully remotely.
This allows patients and caregivers to detect infections hours earlier, helping to avoid hospitalizations, preserve the catheter, and stay on peritoneal dialysis longer.
Our early proof-of-concept study demonstrated that DialySafe’s sensor detects infection-related changes in dialysis fluid up to 33× more sensitively than clinical thresholds set by the International Society on Peritoneal Dialysis (ISPD), using simulated effluent with spiked bacterial and human K562 cell concentrations
Our first-generation prototype is actively being tested and refined at the Rice Nexus @ The Ion, with built-in clip-on sensors designed for seamless integration into existing peritoneal dialysis workflows paving the way for pre-clinical trials
Our Remote Patient Monitoring (RPM) platform includes a clinician-facing dashboard and patient mobile app that make it easy to view trends, receive alerts, and track real-time infection risk, streamlining care and supporting early intervention from anywhere